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Archive of posts tagged frequency filter

The frequency filter Hardy Weinberg dreamed of

You are suspecting a recessive mode of inheritance. What cutoff for the frequency filter should you select? Well, it depends, are you looking for a homozygous pathogenic mutation or compound heterozygotes? This makes a big difference and the Hardy-Weinberg principle might help you to decide. Let’s review the math: In a sufficiently large population there [...]